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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Resveratrol, Docetaxel
Phytochemical Name Resveratrol (PubChem CID: 445154 )
Anticancer drug Name Docetaxel (PubChem CID: 148124 )
Structure of
Phytochemical
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2D MOL 3D MOL
Structure of
Anticancer Drug
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Enhancing Drug Efficacy
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Combination Pair ID: 377
Pair Name Resveratrol, Docetaxel
Disease Info [ICD-11: 2C82] Prostate cancer Investigative
Biological Phenomena Induction-->Necroptosis
Gene Regulation Up-regulation Phosphorylation ATM hsa472
Up-regulation Phosphorylation ATR hsa545
Up-regulation Phosphorylation H2AX hsa3014
In Vitro Model LNCaP Prostate carcinoma Homo sapiens (Human) CVCL_0395
Result We report resveratrol as an adjuvant drug candidate for improving the outcome of treatment in DTX therapy. Although the underlying mechanisms of necroptosis should be investigated comprehensively, targeting apoptosis and necroptosis simultaneously in the treatment of cancer can be a useful strategy for the development of promising drug candidates.
03. Reference
No. Title Href
1 Synergistic anticancer activity of resveratrol in combination with docetaxel in prostate carcinoma cells. Nutr Res Pract. 2021 Feb;15(1):12-25. doi: 10.4162/nrp.2021.15.1.12. Click
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