Pair Name | Resveratrol, Docetaxel | ||
Phytochemical Name | Resveratrol (PubChem CID: 445154 ) | ||
Anticancer drug Name | Docetaxel (PubChem CID: 148124 ) | ||
Structure of Phytochemical |
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2D
MOL
3D
MOL
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Structure of Anticancer Drug |
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2D
MOL
3D
MOL
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Pair Name | Resveratrol, Docetaxel | |||
Disease Info | [ICD-11: 2C82] | Prostate cancer | Investigative | |
Biological Phenomena | Induction-->Necroptosis | |||
Gene Regulation | Up-regulation | Phosphorylation | ATM | hsa472 |
Up-regulation | Phosphorylation | ATR | hsa545 | |
Up-regulation | Phosphorylation | H2AX | hsa3014 | |
In Vitro Model | LNCaP | Prostate carcinoma | Homo sapiens (Human) | CVCL_0395 |
Result | We report resveratrol as an adjuvant drug candidate for improving the outcome of treatment in DTX therapy. Although the underlying mechanisms of necroptosis should be investigated comprehensively, targeting apoptosis and necroptosis simultaneously in the treatment of cancer can be a useful strategy for the development of promising drug candidates. |
No. | Title | Href |
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1 | Synergistic anticancer activity of resveratrol in combination with docetaxel in prostate carcinoma cells. Nutr Res Pract. 2021 Feb;15(1):12-25. doi: 10.4162/nrp.2021.15.1.12. | Click |